He stepped into mainstream politics with election as an MLA in Andhra Pradesh Assembly in 1978. He was re-elected as the MLA in 1983 as well. Naidu is also a two-time BJP national party president, between July-December 2002 and the second time between January-December 2004. He also served as a BJP vice president from April 2005 to January 2006. Naidu is a four-time Rajya Sabha MP, first elected in the Upper House in 1998 from Karnataka.
Before nomination to vice-president post, Venkaiah Naidu was Union Minister of Housing and Urban Poverty Alleviation and Information and Broadcasting Minister under the Narendra Modi government. Naidu is also the founder of Swarna Bharath Trust, a social service organization.
- Dr. Sarvepalli Radhakrishnan was the first Vice President of India (between 1952 to 1962).
- Sh. M. Hamid Ansari and Dr. Sarvepalli Radhakrishnan were the two VPs who were there for the period of 10 years (two tenures).