Biggest Pharmaceutical Company in the World 2025, List of Top-10

The pharmaceutical industry stands as a cornerstone of modern healthcare, providing essential medications and treatments to people worldwide. Within this dynamic sector, several companies emerge as leaders, driving innovation, research, and development. Here, we delve into the world’s top 10 biggest pharmaceutical companies, highlighting their global impact and contributions to healthcare.

What are Pharmaceutical Companies?

Pharmaceutical companies, often referred to as pharma companies, are organizations primarily engaged in the research, development, manufacturing, and distribution of medications and healthcare products. These companies play a critical role in advancing medical science, producing drugs to treat and prevent various diseases, and improving overall public health outcomes through innovation and access to essential medications and therapies.

Largest Pharma Company in the World 2025

Johnson & Johnson (NYSE: JNJ) stands as the undisputed leader among the largest pharmaceutical companies globally in 2025. With a staggering total market capitalization of $406.2 billion and a remarkable total trailing twelve-month revenue of $94.9 billion, Johnson & Johnson has secured its position at the forefront of the pharmaceutical industry. Notably, the company’s pivotal role in developing a successful Covid-19 vaccine further solidifies its status as a key player in global healthcare.

An Overview of Johnson & Johnson, the Biggest Pharma Company of the World

Here are some of the key facts related to Johnson & Johnson (NYSE: JNJ), the biggest pharma company in the world:

• Name: Johnson & Johnson (J&J)
• Type: Public company
• Traded as: NYSE: JNJ
• Industry: Pharmaceutical, Medical Technology
• Founded: January 1886 in New Brunswick, New Jersey, United States
• Founders: Robert Wood Johnson I, James Wood Johnson, Edward Mead Johnson
• Headquarters: New Brunswick, New Jersey, U.S.
• Area served: Worldwide
• Key people: Joaquin Duato (Chairman & CEO)
• Revenue: $94.94 billion (2022)
• Operating income: $21.73 billion (2022)
• Net income: $17.94 billion (2022)
• Total assets: $187.4 billion (2022)
• Total equity: $76.80 billion (2022)
• Number of employees: 130,000 (August 2023)
• Website: jnj.com
• Subsidiaries: Abiomed, Acclarent, Actelion, Cilag, DePuy Synthes, Ethicon, Janssen Biotech, Janssen Pharmaceuticals, Janssen Vaccines, Johnson & Johnson Vision, Mentor, Synthes

Top-10 Biggest Pharmaceutical Companies in the World By 2025

Johnson & Johnson, with the market capitalization value of $406.2 billion, claims the title of the biggest pharmaceutical company in the world, followed by Pfizer Inc., Merck & Co., Inc., and Roche Group.

Here is the list of top-10 biggest pharmaceutical companies in the world by 2025:

LARGEST PHARMACEUTICAL COMPANIES IN THE WORLD 2025
Rank	Company	Ticker	Market Cap.	TTM Revenue
1.	Johnson & Johnson	JNJ	$406.2B	$94.9B
2.	Pfizer Inc.	PFE	$234.4B	$100.3B
3.	Merck & Co., Inc.	MRK	$278.6B	$59.3B
4.	Roche Group		$238.0B	$68.5B
5.	AbbVie Inc.	ABBV	$270.2B	$58.1B
6.	Novartis AG	NVS	$183.2B	$51.8B
7.	Bayer		$58.6B	$52.8B
8.	Eli Lilly and Company	LIY	$305.7B	$28.5B
9.	AstraZeneca PLC	AZN	$209.3B	$44.4B
10.	Novo Nordisk A/S	NVO	$322.1B	$25.1B

World’s Largest Pharmaceutical Company – Jhonson & Johnson

 

Ticker: JNJ

Market Capitalization: $406.2B

TTM Revenue: $94.9B

Johnson & Johnson (NYSE: JNJ) stands as the world’s largest pharmaceutical company, with a market capitalization of $406.2 billion as of February 26, 2023, and a total trailing twelve months revenue of $94.9 billion. Renowned for developing a successful Covid-19 vaccine, it remains highly profitable despite legal challenges.

Second Biggest Pharmaceutical Company – Pfizer Inc.

 

Ticker: PFE

Market Capitalization: $234.4B

TTM Revenue: $100.3B

Pfizer Inc. (NYSE: PFE) ranks as the world’s second-largest pharmaceutical company, boasting a market capitalization of $234.4 billion as of February 26, 2023, and a total trailing twelve months revenue of $100.3 billion. Despite breakthroughs like its RSV vaccine, challenges such as FDA warnings highlight ongoing concerns.

Third Largest Pharmaceutical Company in the World – Merck & Co., Inc.

 

Ticker: MRK

Market Capitalization: $278.6B

TTM Revenue: $59.3B

Merck & Co., Inc. (NYSE: MRK) stands as the world’s third-largest pharmaceutical company, boasting a market capitalization of $278.6 billion as of February 26, 2023, and total trailing twelve months revenue of $59.3 billion. Despite its historical lineage and global presence, recent setbacks in EU approvals for its Covid pill pose challenges.