LoI Signed to Set Up Centre of Excellence for CRISPR Research and Innovation

India has taken an important step in strengthening its biotechnology and gene editing capabilities with the signing of a Letter of Intent (LoI) to establish a Centre of Excellence for CRISPR Innovation and Translation (CoE-CIT). The announcement was made on December 22, 2025 by the Press Information Bureau. The proposed centre aims to bridge the gap between laboratory research and real world clinical applications, ensuring that advanced scientific discoveries directly benefit society.

Context

• A new Letter of Intent (LoI) has been signed to set up the Centre of Excellence for CRISPR Innovation and Translation (CoE-CIT).
• The initiative is a public private partnership between the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bengaluru and CRISPRBITS Private Limited, Delhi.
• It aims to convert scientific research in laboratories into real-world clinical applications.
• The announcement was made on 22 December 2025.

Details of the Initiative

The CoE-CIT will combine JNCASR’s expertise in biomedical sciences with CRISPRBITS applied gene-editing capabilities.

Goals include,

• Bridging the gap between laboratory research and clinical application (‘bench to bed’).
• Developing therapeutic solutions for healthcare.
• Serving as a national model for academia–industry collaboration.
• This is one of the first partnerships of its kind in India.

CRISPR Technology

• CRISPR is a gene editing technology that allows scientists to make precise changes in DNA.
• It is used in healthcare, diagnostics, and biotechnology.
• CRISPR can help develop affordable and scalable solutions for diseases and genetic disorders.
• India has been promoting such technology to strengthen its biotech and innovation ecosystem.

Expected Impact

• Healthcare: Faster development of gene-based diagnostics and therapies.
• Innovation ecosystem: Strengthens collaboration between academia and private sector.
• Society: Affordable solutions can reach more patients, improving public health.
• Science and research: Encourages more translational research in India.

National and Societal Significance

The CoE-CIT reflects India’s push towards self-reliance in advanced technologies and aligns with national goals in healthcare innovation and biotechnology. By focusing on translation and affordability, the centre supports,

• Strengthening India’s biotech sector
• Reducing dependence on imported technologies
• Delivering real benefits to patients and society

Key Takeaways

• A Letter of Intent was signed on December 22, 2025 to establish CoE-CIT
• The centre focuses on CRISPR Innovation and Translation
• Partners: JNCASR Bengaluru and CrisprBits Private Limited
• JNCASR is an autonomous institute under the Department of Science and Technology (DST)
• The initiative aims to bridge the bench-to-bedside gap
• It is a public–private partnership model for biotechnology innovation

Question

Q. The CoE-CIT initiative is a collaboration between which two entities?

A. AIIMS Delhi and Serum Institute of India
B. JNCASR Bengaluru and CRISPRBITS Private Limited, Delhi
C. IIT Delhi and Bharat Biotech
D. DRDO and RRU